Famous
Famo.us is a powerful JavaScript framework designed to build rich, interactive web applications. It is the only framework that provides an open source 3D layout engine fully integrated with a 3D physics-based animation engine that can render to DOM, Canvas, or WebGL. Famo.us is currently in public beta.
Durandal
A cross-device, cross-platform client framework written in JavaScript and designed to make building Single Page Applications (SPAs) easy to create and maintain.
Sails
Realtime MVC Framework for Node.js
Aura
A scalable, event-driven JavaScript architecture for developing widget-based applications. Works with Backbone.js and other frameworks.
Layr
Dramatically simplify full‑stack development
Blizzard.js
A promise-based Node.JS library for the Blizzard Battle.net Community Platform API
Bem Core
BEM Core Library
Enyo
A JavaScript application framework emphasizing modularity and encapsulation
Loopback
LoopBack makes it easy to build modern applications that require complex integrations.
Wee
Blueprint for modern web development
Serenade.js
Client side MVC framework
Pagerjs
The Single Page Application Framework for KnockoutJS
Electron
Build cross-platform desktop apps with JavaScript, HTML, and CSS
Simplecart
A simple javascript shopping cart that easily integrates with your current website.
Mithril.js
A Javascript Framework for Building Brilliant Applications
Redux Elm
The Elm Architecture in JavaScript http://salsita.github.io/redux-elm/