Sails
Realtime MVC Framework for Node.js
Aura
A scalable, event-driven JavaScript architecture for developing widget-based applications. Works with Backbone.js and other frameworks.
Layr
Dramatically simplify full‑stack development
Flakes
Flakes is an Admin Template Framework. A combination of CSS Libraries, JavaScript Libraries and Design files that help you build business tools very quickly.
Blizzard.js
A promise-based Node.JS library for the Blizzard Battle.net Community Platform API
Bem Core
BEM Core Library
Enyo
A JavaScript application framework emphasizing modularity and encapsulation
Loopback
LoopBack makes it easy to build modern applications that require complex integrations.
Wee
Blueprint for modern web development
Serenade.js
Client side MVC framework
Pagerjs
The Single Page Application Framework for KnockoutJS
Electron
Build cross-platform desktop apps with JavaScript, HTML, and CSS
Mithril.js
A Javascript Framework for Building Brilliant Applications
Redux Elm
The Elm Architecture in JavaScript http://salsita.github.io/redux-elm/
Thinkjs
Use full ES2015+ features to develop Node.js applications, Support TypeScript.
Knockout
Knockout makes it easier to create rich, responsive UIs with JavaScript