Sails
Realtime MVC Framework for Node.js
YUI3
YUI is a free, open source JavaScript and CSS library for building richly interactive web applications.
Layr
Dramatically simplify full‑stack development
Joosy
Joosy is a browser applications framework. That is based on Rails, CoffeeScript and love.
Maria
The MVC framework for JavaScript applications. The real MVC. The Smalltalk MVC. The Gang of Four MVC.
Terrificjs
Terrific JavaScript Framework
Black Hole.js
Renders black hole gravitational lensing effects in an image canvas using WebGL, glfx.js, and numeric.js
Batman
Fighting Crime and Kicking Apps
Montage
Core framework: Montage simplifies the development of rich HTML5 applications by providing modular components, real-time two-way data binding, CommonJS dependency management, and many more conveniences. Join us on irc.freenode.net#montage or https://groups.google.com/d/forum/montagejs
Thinkjs
Use full ES2015+ features to develop Node.js applications, Support TypeScript.
Flux
Application Architecture for Building User Interfaces
Angular Meteor
Combining the simplicity and power of AngularJS and Meteor
Blizzard.js
A promise-based Node.JS library for the Blizzard Battle.net Community Platform API
Ink
An HTML5/CSS3 framework used at SAPO for fast and efficient website design and prototyping
Skel
A lightweight responsive framework for the www
Durandal
A cross-device, cross-platform client framework written in JavaScript and designed to make building Single Page Applications (SPAs) easy to create and maintain.
Cerebral
A state controller with its own debugger