Sails
Realtime MVC Framework for Node.js
Aurelia Framework
The aurelia framework brings together all the required core aurelia libraries into a ready-to-go application-building platform.
Durandal
A cross-device, cross-platform client framework written in JavaScript and designed to make building Single Page Applications (SPAs) easy to create and maintain.
Loopback
LoopBack makes it easy to build modern applications that require complex integrations.
Ink
An HTML5/CSS3 framework used at SAPO for fast and efficient website design and prototyping
Uranium
Universal css-in-js media queries for React Native and React
Ractive
Next-generation DOM manipulation
Redhooks
Predictable state container for React apps written using Hooks
Chaplin
An Application Architecture Using Backbone.js
Flux
Application Architecture for Building User Interfaces
Montage
Core framework: Montage simplifies the development of rich HTML5 applications by providing modular components, real-time two-way data binding, CommonJS dependency management, and many more conveniences. Join us on irc.freenode.net#montage or https://groups.google.com/d/forum/montagejs
Qooxdoo
A Universal JavaScript Framework
Famous
Famo.us is a powerful JavaScript framework designed to build rich, interactive web applications. It is the only framework that provides an open source 3D layout engine fully integrated with a 3D physics-based animation engine that can render to DOM, Canvas, or WebGL. Famo.us is currently in public beta.
Postal.js
JavaScript pub/sub library supporting some advanced subscription features, plus message capture and replay
Winjs
WinJS project by Microsoft Open Technologies
Foundation
The most advanced responsive front-end framework in the world. Quickly create prototypes and production code for sites and apps that work on any kind of device.