Batman
Fighting Crime and Kicking Apps
Winjs
WinJS project by Microsoft Open Technologies
Flux
Application Architecture for Building User Interfaces
Qooxdoo
A Universal JavaScript Framework
Uranium
Universal css-in-js media queries for React Native and React
Javascript State Machine
A finite state machine javascript micro framework
Chaplin
An Application Architecture Using Backbone.js
Loopback
LoopBack makes it easy to build modern applications that require complex integrations.
Durandal
A cross-device, cross-platform client framework written in JavaScript and designed to make building Single Page Applications (SPAs) easy to create and maintain.
Foundation
The most advanced responsive front-end framework in the world. Quickly create prototypes and production code for sites and apps that work on any kind of device.
Director
a tiny and isomorphic URL router for JavaScript
Aura
A scalable, event-driven JavaScript architecture for developing widget-based applications. Works with Backbone.js and other frameworks.
Inferno
An extremely fast, React-like JavaScript library for building modern user interfaces
Flight
A lightweight, component-based JavaScript framework
Layr
Dramatically simplify full‑stack development
Oraclejet
Oracle JET is a modular JavaScript Extension Toolkit for developers working on client-side applications.
Montage
Core framework: Montage simplifies the development of rich HTML5 applications by providing modular components, real-time two-way data binding, CommonJS dependency management, and many more conveniences. Join us on irc.freenode.net#montage or https://groups.google.com/d/forum/montagejs