Qooxdoo
A Universal JavaScript Framework
Flight
A lightweight, component-based JavaScript framework
Winjs
WinJS project by Microsoft Open Technologies
Chaplin
An Application Architecture Using Backbone.js
Javascript State Machine
A finite state machine javascript micro framework
Sails
Realtime MVC Framework for Node.js
Durandal
A cross-device, cross-platform client framework written in JavaScript and designed to make building Single Page Applications (SPAs) easy to create and maintain.
Director
a tiny and isomorphic URL router for JavaScript
Uranium
Universal css-in-js media queries for React Native and React
Foundation
The most advanced responsive front-end framework in the world. Quickly create prototypes and production code for sites and apps that work on any kind of device.
Framework7
Full Featured HTML Framework For Building iOS & Android Apps
Inferno
An extremely fast, React-like JavaScript library for building modern user interfaces
Loopback
LoopBack makes it easy to build modern applications that require complex integrations.
Flux
Application Architecture for Building User Interfaces
Layr
Dramatically simplify full‑stack development
Oraclejet
Oracle JET is a modular JavaScript Extension Toolkit for developers working on client-side applications.
Montage
Core framework: Montage simplifies the development of rich HTML5 applications by providing modular components, real-time two-way data binding, CommonJS dependency management, and many more conveniences. Join us on irc.freenode.net#montage or https://groups.google.com/d/forum/montagejs